The metabolism of C2-compounds in micro-organisms. 9. Role of the glyoxylate cycle in protozoal glyconeogenesis.
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چکیده
منابع مشابه
A central role for the peroxisomal membrane in glyoxylate cycle function.
The glyoxylate cycle provides the means to convert C2-units to C4-precursors for biosynthesis, allowing growth on fatty acids and C2-compounds. The conventional view that the glyoxylate cycle is contained within peroxisomes in fungi and plants is no longer valid. Glyoxylate cycle enzymes are located both inside and outside the peroxisome. Thus, the operation of the glyoxylate cycle requires tra...
متن کاملThe metabolism of C2 compounds in micro-organisms. 7. Preparation and properties of crystalline tartronic semialdehyde reductase.
The biosynthesis of cell materials by Pseudomonas spp. growing on glycollate (Kornberg & Gotto, 1959, 1961), on glycine (Callely & Dagley, 1959), on oxalate (Quayle & Keech, 1959) or on other substrates catabolized to glyoxylate (Gray, Gerhart & Brooke, 1959) has been shown to be effected by a sequence of reactions in which, initially, glyoxylate is converted into glycerate. This transformation...
متن کاملThe ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate.
Acetyl-CoA assimilation was extensively studied in organisms harboring the glyoxylate cycle. In this study, we analyzed the metabolism of the facultative methylotroph Methylobacterium extorquens AM1, which lacks isocitrate lyase, the key enzyme in the glyoxylate cycle, during growth on acetate. MS/MS-based proteomic analysis revealed that the protein repertoire of M. extorquens AM1 grown on ace...
متن کاملAnaerobic induction of isocitrate lyase and malate synthase in submerged rice seedlings indicates the important metabolic role of the glyoxylate cycle.
The glyoxylate cycle is a modified form of the tricarboxylic acid cycle that converts C2 compounds into C4 dicarboxylic acids at plant developmental stages. By studying submerged rice seedlings, we revealed the activation of the glyoxylate cycle by identifying the increased transcripts of mRNAs of the genes of isocitrate lyase (ICL) and malate synthase (MS), two characteristic enzymes of the gl...
متن کاملHow half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathway.
For bacterial growth on substrates with only one or two carbon atoms, special assimilation pathways are required. In 1957, the glyoxylate cycle of Kornberg and Krebs was described for bacterial growth on C2 compounds such as ethanol and acetate. However this pathway did not operate in some photosynthetic bacteria and in some methylotrophs when they were growing on C2 compounds, so an alternativ...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 86 شماره
صفحات -
تاریخ انتشار 1963